Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Izraeli, S; Henn, T; Strobl, H; Ludwig, WD; Kovar, H; Haas, OA; Harbott, J; Bartram, CR; Gadner, H; Lion, T.
Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia.
Leukemia. 1993; 7(12):2054-2056
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- Co-Autor*innen der Med Uni Graz
- Strobl Herbert
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- Abstract:
- The translocation t(1;19)(q23;p13) in pediatric patients with acute lymphoblastic leukemia (ALL) was demonstrated in early reports to result in a consistent fusion between the E2A and PBX1 gene sequences and in the expression of a uniform, chimeric E2A/PBX1 mRNA with transforming potential. More recent observations suggested that cytogenetically identical t(1;19) translocations can result in the transcription of different mRNA species and that expression of the E2A/PBX1 message may be restricted to patients with the t(1;19) who display a pre-B phenotype of ALL. To further assess the correlation between the immunologic subtypes of the disease and specific genetic alterations, we have performed cytogenetic and molecular analyses in 221 children with B-lineage ALL. Expression of the chimeric E2A/PBX1 message was detected in 21 patients. Out of 14 patients, in whom cytoplasmic immunoglobulin (cig) analyses were available, no less than four had a cig- B-cell precursor ALL, whereas 10 displayed a cig+ B-ALL immunophenotype. These findings are at variance with a recent report in which expression of the E2A/PBX1 message was linked exclusively to a subset of patients who displayed a cig+ pre-B-cell precursor phenotype of ALL. In seven cases diagnosed before 1986, cig analyses were not available, and consequently E2A/PBX1 expression could not be correlated to a particular immunological subtype of B-cell precursor ALL. Our results have important implications for the detection of residual disease in pediatric patients where expression of the typical E2A/PBX1 mRNA may occur both in cig+ (pre-B) and cig- (early pre-B) immunologic subtypes of ALL.
- Find related publications in this database (using NLM MeSH Indexing)
- Child -
- Chromosomes, Human, Pair 1 -
- Chromosomes, Human, Pair 19 -
- Cytoplasm - immunology
- Gene Expression -
- Humans -
- Immunoglobulin Heavy Chains - metabolism
- Immunophenotyping -
- Oncogene Proteins, Fusion - genetics
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
- RNA, Messenger - metabolism
- Transcription, Genetic -
- Translocation, Genetic -