Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, K; Graier, WF; Kostner, GM; Mayer, B; Kukovetz, WR.
Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein.
Biochem Biophys Res Commun. 1990; 172(2):614-619
Doi: 10.1016/0006-291X(90)90718-3
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- Co-Autor*innen der Med Uni Graz
- Graier Wolfgang
- Kostner Gerhard
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- Abstract:
- In the presence of oxidized low-density lipoprotein the stimulatory effects of nitric oxide, sodium nitroprusside and S-nitrosoglutathione on soluble guanylate cyclase partially purified from bovine platelets were diminished in a concentration-dependent manner with IC50 values around 100 micrograms total cholesterol/ml. This inhibitory effect was potentiated about 10-fold when the enzyme was pre-incubated with the lipoprotein for 10 minutes at 37 degrees C which indicates a direct interaction of the lipoprotein with the guanylate cyclase. As oxidized low-density lipoprotein is present in the wall of atherosclerotic arteries, we suggest that the impaired response of atherosclerotic blood vessels to vasodilators may be due to a diminished activation of smooth muscle guanylate cyclase.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Platelets - enzymology
- Cattle - enzymology
- Cytosol - enzymology
- Glutathione - analogs and derivatives
- Guanylate Cyclase - blood
- Humans - blood
- Kinetics - blood
- Lipoproteins - blood
- Nitric Oxide - pharmacology
- Nitroprusside - pharmacology
- Nitroso Compounds - pharmacology
- Oxidation-Reduction - pharmacology
- S-Nitrosoglutathione - pharmacology
- Vasodilator Agents - pharmacology