Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Pilz, S; Boehm, BO; Grammer, TB; Obermayer-Pietsch, B; März, W.
Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography.
Clin Endocrinol (Oxf). 2012; 77(3):475-483
Doi: 10.1111/j.1365-2265.2012.04371.x
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Obermayer-Pietsch Barbara
- Pilz Stefan
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- Abstract:
- Context Low levels of 25-hydroxyvitamin D [25(OH)D] and free testosterone (FT) are both associated with increased mortality. Experimental studies show a complex interplay of vitamin D and androgen metabolism suggesting that a deficiency of both hormones may be associated with a particularly adverse clinical outcome. Objective To evaluate the impact of parallel FT and 25(OH)D deficiency in a large cohort of older men. Design We measured total testosterone (TT), sex hormone-binding globulin and 25(OH)D levels in 2069 men who were routinely referred for coronary angiography (1997-2000). Main outcome measures Cox proportional hazard ratios (HRs) (with 95% confidence intervals) for mortality from all causes, cardiovascular and noncardiovascular causes according to combined deficiency of FT and 25(OH)D. Results In multivariate-adjusted analyses, we found an increased risk for all-cause mortality, cardiovascular and noncardiovascular mortality for men in the lowest FT [HR 1.26 (1.031.54), 1.24 (0.961.60) and 1.39 (1.001.93), respectively] and 25(OH)D quartile [HR 1.77 (1.472.13), 1.65 (1.292.10) and 1.89 (1.382.60) respectively] compared with men in higher FT and 25(OH)D quartiles. There was no independent association of TT levels with mortality. Multivariate-adjusted HRs progressively increased with the number of hormones (FT and 25(OH)D) in the lowest quartile [0 vs 2 hormone deficiencies: 2.11 (1.602.79) for all cause, 1.77 (1.232.55) for cardiovascular and 2.33 (1.453.47) for noncardiovascular mortality, respectively]. Conclusion A combined deficiency of FT and 25(OH)D is significantly associated with fatal events in a large cohort of men referred for coronary angiography.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aging - blood
- Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality
- Cohort Studies -
- Coronary Angiography -
- Coronary Angiography - epidemiology
- Humans -
- Male -
- Middle Aged -
- Prospective Studies -
- Risk Factors -
- Testosterone - blood Testosterone - deficiency
- Vitamin D - analogs and derivatives Vitamin D - blood
- Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - mortality