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Strauss, RW; Kampik, A; Neubauer, AS.
Topographic, 3D and Quantitative analysis of autofluorescence in dry, age-related macular degeneration.
Klin Monbl Augenheilkd. 2007; 224(12):927-931 Doi: 10.1055/s-2007-963743
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Leading authors Med Uni Graz: Strauß Rupert
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Abstract:: Objective: Autofluorescence of the retina allows one to quantify and follow the extent and progression of dry, age-related macular degeneration (ARMD) changes. The objective of this Study was to compare different analysis methods for displaying autofluorescence images. Methods: In a consecutive series of 15 patients with mild dry AMD and 15 patients without retinal pathologies, one 30 degrees autofluorescence image was obtained with the Heidelberg retina angio-graph (HRA). Evaluation was performed by observers masked to the clinical group for each of the three analysis displays: topographic map in false colours (similar to height lines in maps), 3D display of optical density and quantitative, standardised evaluation of optical density values. Results: For the 30 eyes included, grading of ARMD versus normal yielded a sensitivity of 83 -92% for the topographic map, 58-83% for the 3 D and 75-83% for quantitative optical density display. The corresponding specificity was 87 93% for the topographic map, 53-60% for the 3D and 67-80% for the quantitative optical density display. Conclusions: Analysis by topographic mapping is suitable to supply quantitative information of optical density for evaluating autofluorescence images. In spite of being illustrative, a 3D display of optical density does not offer sufficient properties for analysis.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Disease Progression -; Female -; Fluorescein Angiography -; Humans -; Image Processing, Computer-Assisted -; Imaging, Three-Dimensional -; Macular Degeneration - pathology; Male -; Middle Aged -; Reference Values -; Retina - pathology; Sensitivity and Specificity -
Find related publications in this database (Keywords): retina; imaging; autofluorescence