Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Jäger, H; Popescu, M; Reibnegger, G; Werner, ER; Dierich, MP; Kaboth, W; Tilz, GP; Wachter, H.
Immune activation markers to predict AIDS and survival in HIV-1 seropositives.
Immunol Lett. 1990; 26(1):75-79
Doi: 10.1016/0165-2478(90)90178-S
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Tilz Gernot
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- Abstract:
- Neopterin concentrations in body fluids of HIV-1 seropositives provide predictive information. In 1986, we examined serum and urine neopterin concentrations in 29 HIV-1 seropositives. Serum levels of soluble IL-2 receptor (sIL2R), soluble CD8 (sCD8), tumour necrosis factor alpha (TNF-alpha) and circulating immune complexes (CIC) were retrospectively analysed in 1989. All individuals had increased serum and urine neopterin, sIL2R and CIC concentrations, 27/29 had increased sCD8 concentrations, whereas all had normal TNF-alpha levels. During a 3-year follow-up, high urine and serum neopterin concentrations were significantly associated with progression to AIDS and with the occurrence of AIDS-associated death. Both neopterin variables were of similar predictive value (p less than 0.001, generalized Wilcoxon test). sIL2R concentrations were of borderline significance in predicting the onset of AIDS (p = 0.05). All other parameters lacked predictive information in our study. We conclude, that chronic immune activation is detectable in almost all HIV-1 seropositives. Chronic immune activation may be associated with HIV-1 replication and may contribute to the immunopathology of HIV-1 infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - immunology
- Adult - immunology
- Antigen-Antibody Complex - blood
- Antigens, CD8 - blood
- Antigens, Differentiation, T-Lymphocyte - blood
- Biological Markers - blood
- Biopterin - analogs and derivatives
- Cohort Studies - analogs and derivatives
- HIV Seropositivity - immunology
- HIV-1 - immunology
- Humans - immunology
- Male - immunology
- Middle Aged - immunology
- Neopterin - immunology
- Predictive Value of Tests - immunology
- Prognosis - immunology
- Receptors, Interleukin-2 - blood
- Tumor Necrosis Factor-alpha - analysis