Medizinische Universität Graz - Research portal
Selected Publication:
Boike, GM; Petru, E; Sevin, BU; Averette, HE; Chou, TC; Penalver, M; Donato, D; Schiano, M; Hilsenbeck, SG; Perras, J.
Chemical enhancement of cisplatin cytotoxicity in a human ovarian and cervical cancer cell line.
Gynecol Oncol. 1990; 38(3):315-322
Doi: 10.1016/0090-8258(90)90065-S
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- Co-authors Med Uni Graz
- Petru Edgar
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- Abstract:
- While many advances have been made in the chemotherapy of gynecologic cancers, treatment failures remain a major clinical problem. A growing understanding of the mechanisms of tumor cell resistance to antineoplastic drugs provides a framework for the development of chemotherapy regimens containing agents capable of modulating tumor response. Using a short-term ATP bioluminescence assay we studied the ability of two methylxanthines (caffeine, pentoxifylline) and an inhibitor of ADP-ribosyl transferase (3-aminobenzamide) to enhance cisplatin cytotoxicity in gynecologic cancer cell lines. Our findings of significantly enhanced cisplatin-induced cytotoxicity with two different analysis techniques confirms the effectiveness of these agents. These results may have future clinical significance.
- Find related publications in this database (using NLM MeSH Indexing)
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