Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Donnerer, J; Amann, R.
Capsaicin-evoked neuropeptide release is not dependent on membrane potential changes.
Neurosci Lett. 1990; 117(3):331-334
Doi: 10.1016/0304-3940(90)90686-4
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- Führende Autor*innen der Med Uni Graz
- Donnerer Josef
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- Abstract:
- In high K(+)-depolarized spinal cord slices, capsaicin evoked the in vitro release of substance P and calcitonin gene-related peptide (CGRP) from central terminals of C-fibre afferents. This shows that capsaicin-induced release of neuropeptides from sensory afferents is not dependent on membrane potential changes, and that capsaicin-induced Ca2(+)-influx into nerve terminals does not require activation of voltage-sensitive calcium channels (VSCC). On the other hand, in the continuous presence of capsaicin, high K+ did not evoke release of CGRP, but only released substance P, which most likely originated from intrinsic substance P- containing neurones in the spinal cord.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - metabolism
- Capsaicin - pharmacology
- Male - pharmacology
- Membrane Potentials - drug effects
- Neurons, Afferent - drug effects
- Neuropeptides - metabolism
- Potassium - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Spinal Cord - cytology
- Substance P - metabolism