Medizinische Universität Graz - Research portal
Selected Publication:
Petru, E; Boike, G; Sevin, BU.
Potentiation of cisplatin cytotoxicity by methylxanthines in vitro.
J Cancer Res Clin Oncol. 1990; 116(5):431-433
Doi: 10.1007/BF01612988
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- Petru Edgar
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- Abstract:
- The ability of two supposed DNA-repair inhibitors to modulate cisplatin-induced cytotoxicity in a human ovarian cancer cell line (CAOV-3) and a human cervical cancer cell line (Me-180) was investigated using a short-term chemosensitivity assay based on bioluminescence of cellular adenosine triphosphate (ATP). Cisplatin concentrations bracketing the reported peak plasma concentration (2.5 micrograms/ml) were used and the 50% inhibitory concentrations were determined by linear regression of log-transformed survival data. At 2.5 mM, the methylxanthine caffeine enhanced cisplatin sensitivity 2.9-fold in CAOV-3 cells and 2.7-fold in Me-180 cells. At 2.5 mM, pentoxifylline, a closely related methylxanthine, increased cisplatin sensitivity 2.9-fold in CAOV-3 cells and 3.4-fold in Me-180 cells. Chemical modification of cisplatin-induced cytotoxicity by assumed inhibition of DNA-repair mechanisms may hold promise for clinical application in the treatment of gynecological cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - biosynthesis
- Caffeine - pharmacology
- Cell Survival - physiology
- Cisplatin - therapeutic use
- Dose-Response Relationship, Drug - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Ovarian Neoplasms - drug therapy
- Xanthines - pharmacology