Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Czaja, AJ; Cookson, S; Constantini, PK; Clare, M; Underhill, JA; Donaldson, PT.
Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis.
Gastroenterology. 1999; 117(3):645-652
Doi: 10.1016/S0016-5085(99)70458-0
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Constantini-Kump Patrizia
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background & Aims: Polymorphisms that control cytokine production can affect immunoregulation. The frequency and consequences of these polymorphisms in type 1 autoimmune hepatitis were determined. Methods: DNA samples from 155 patients and 102 ethnically similar normal individuals were assessed by polymerase chain reaction for polymorphisms of 4 different cytokine-producing genes. Results: Only genotypes associated with the guanine to adenine substitution at position -308 of the tumor necrosis factor gene occurred more commonly in patients than in normal subjects (56% vs. 26%; P < 0.001). Patients with this polymorphism had the HLA DRB1*0301 allele (81% vs. 10%; P < 0.000001) and A1-B8-DRB1*0301 (66% vs. 0%; P < 0.000001) phenotype more frequently and HLA DRB1*04 alleles less often (24% vs. 67%; P < 0.000001). They also entered remission less commonly (56% vs. 78%; P = 0.01), had treatment failure more often (20% vs. 7%; P = 0.03), and developed cirrhosis more frequently (40% vs. 19%; P = 0.05). These latter differences, however, were not statistically significant by adjusted P value. Conclusions: A polymorphism of the tumor necrosis factor gene occurs more commonly in patients with type 1 autoimmune hepatitis than in normal subjects; it is associated with a poorer response to corticosteroids. The polymorphism may be inherited as part of the extended A1-B8-DRB1*0301 haplotype and may affect both disease expression and behavior.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Autoantibodies - analysis
- Cytokines - biosynthesis Cytokines - genetics
- DNA - analysis
- Female -
- Genotype -
- Glucocorticoids - therapeutic use
- HLA-D Antigens - genetics
- Hepatitis, Autoimmune - drug therapy Hepatitis, Autoimmune - genetics Hepatitis, Autoimmune - immunology Hepatitis, Autoimmune - physiopathology
- Humans -
- Immunosuppressive Agents - therapeutic use
- Male -
- Middle Aged -
- Polymerase Chain Reaction -
- Polymorphism, Genetic -
- Prednisone - therapeutic use
- Treatment Outcome -
- Tumor Necrosis Factor-alpha - genetics