Medizinische Universität Graz - Research portal
Selected Publication:
Constantini, PK; Wawrzynowicz-Syczewska, M; Clare, M; Boron-Kaczmarska, A; McFarlane, IG; Cramp, ME; Donaldson, PT.
Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy.
Liver. 2002; 22(5):404-412
Doi: 10.1034/j.1600-0676.2002.01553.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Constantini-Kump Patrizia
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- Abstract:
- Background/Aims: Though there is a consensus that the HLA DQB1 *0301 allele is important in untreated HCV clearance, this association is not universal and a number of genes outside the major histocompatibility complex may also play a role in host responses to HCV infection. Prime candidates, at present, are the genes encoding pro-inflammatory and immuno-regulatory cytokines. The aim of this study was to investigate the relationship between a number of these candidate genes and both spontaneous and treatment related clearance of hepatitis C virus infection. Methods: Three members of the interleukin-1 gene family: IL-1A , IL-1B and IL-1RN , three polymorphic sites in the interleukin-10 gene promoter (- 1082, - 819, - 592) and two in the tumour necrosis factor-alpha promoter (- 308, - 238) were studied in two independent DNA banks, each with appropriate controls. Standard PCR-based genotyping techniques were used. Results: No significant difference in the distribution of any of the polymorphisms was found in either study set. Conclusions: These findings in two large groups suggest that future investigations should focus on other candidate genes and may support the view that MHC-encoded susceptibility to chronic HCV infection may be determined by MHC class II rather than MHC class III genes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cytokines - genetics
- Female -
- Genetic Predisposition to Disease -
- Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - isolation and purification
- Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology
- Humans -
- Interferon-alpha - therapeutic use
- Interleukin-1 - genetics
- Interleukin-10 - genetics
- Male -
- Middle Aged -
- Polymerase Chain Reaction -
- Polymorphism, Genetic -
- RNA, Viral - analysis
- Tumor Necrosis Factor-alpha - genetics
- Viral Load -
- Viremia - genetics Viremia - immunology
- Find related publications in this database (Keywords)
- hepatitis C virus
- interleukin-1
- interleukin-10
- tumour necrosis factor-alpha
- interferon-gamma