Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Ring, E; Zobel, G.
Hemofiltration in acute neonatal metabolic crisis
Wien Klin Wochenschr. 1992; 104(21):674-677
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Führende Autor*innen der Med Uni Graz: Ring Ekkehard
Co-Autor*innen der Med Uni Graz: Zobel Gerfried
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Abstract:: Continuous arteriovenous hemofiltration (CAVH) and venovenous hemofiltration (CVVH) were successfully used in the treatment of two neonates, one with maple syrup urine disease and the other with ornithine transcarbamylase deficiency. The plasma concentrations of branched-chain amino acids as well as of ammonium decreased to non-toxic values within a few hours and the clinical improvement in the encephalopathy was striking. Our results and a review of the literature show that hemofiltration is more effective than peritoneal dialysis in removing toxic metabolites. The best clearance rates are achieved by intermittent hemodialysis, but continuous hemofiltration is a simple, safe and effective alternative and is sometimes tolerated better by critically ill infants.
Find related publications in this database (using NLM MeSH Indexing): Amino Acids, Branched-Chain - blood; Ammonia - blood; Emergencies - blood; Female - blood; Hemofiltration - methods; Humans - methods; Infant, Newborn - methods; Intensive Care Units, Neonatal - methods; Male - methods; Maple Syrup Urine Disease - enzymology; Ornithine Carbamoyltransferase - deficiency
Find related publications in this database (Keywords): Hemofiltration; Inborn Errors of Metabolism; Metabolic Crisis; Neonates