Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Santangelo, WC; Unger, RH; Orci, L; Dueno, MI; Popma, JJ; Krejs, GJ.
Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration.
Pancreas. 1986; 1(5):464-469
Doi: 10.1097/00006676-198609000-00013
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
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- Abstract:
- A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection. Plasma glucagon concentration (1,500-3,300 pg/ml, normal less than 200) remained elevated during analog therapy as the rash cleared. Only with surgical resection (partial pancreatectomy and partial hepatectomy) did glucagon levels return to normal. The therapeutic benefit caused by the analog in this syndrome differs from that in other endocrine tumor syndromes such as pancreatic cholera, carcinoid, or gastrinoma where circulating levels of tumor-produced agents are suppressed in conjunction with control of symptoms.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antineoplastic Agents - therapeutic use
- Erythema - drug therapy Erythema - etiology
- Female -
- Glucagon - blood
- Glucagonoma - complications Glucagonoma - drug therapy Glucagonoma - surgery
- Humans -
- Octreotide -
- Pancreatic Neoplasms - complications Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - surgery
- Somatostatin - analogs and derivatives Somatostatin - therapeutic use