Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Davis, GR; Camp, RC; Raskin, P; Krejs, GJ.
Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome.
Gastroenterology. 1980; 78(2):346-349
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
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- Abstract:
- The effect of intravenous somatostatin infusion was investigated in a patient with severe secretory diarrhea due to malignant carcinoid syndrome. Continuous somatostatin infusion for 48 hr (4 microgram/kg/hr) reduced stool volume from 2.2 to 0.7 liters/day. Intestinal perfusion studies before intravenous somatostatin infusion revealed decreased water and sodium absorption and jejunal chloride secretion. Somatostatin infusion for 2 hr (8 microgram/kg/hr) reversed chloride secretion to absorption and markedly enhanced water and sodium absorption. These results suggest that somatostatin inhibited a secretory component of water and ion movement in the small bowel of the patient with malignant carcinoid syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Diarrhea - drug therapy Diarrhea - metabolism
- Electrolytes - metabolism
- Female -
- Humans -
- Intestinal Absorption - drug effects
- Jejunum - drug effects
- Malignant Carcinoid Syndrome - complications
- Somatostatin - therapeutic use
- Water-Electrolyte Balance - drug effects