Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Krejs, GJ; Orci, L; Conlon, JM; Ravazzola, M; Davis, GR; Raskin, P; Collins, SM; McCarthy, DM; Baetens, D; Rubenstein, A; Aldor, TA; Unger, RH.
Somatostatinoma syndrome. Biochemical, morphologic and clinical features.
N Engl J Med. 1979; 301(6):285-292
Doi: 10.1056/NEJM197908093010601
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- Führende Autor*innen der Med Uni Graz
- Krejs Günter Josef
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- Abstract:
- Diabetes mellitus, steatorrhea, cholelithiasis and a tumor distorting the duodenum prompted a work-up for somatostatinoma in a 52-year-old man. The responses of pancreatic B-cells but not of A-cells to nutrient stimuli were inhibited, and growth-hormone release was suppressed, suggesting somatostatin resistance in some target tissues. Plasma somatostatin-like immunoreactivity ranged from 9000 to 13,000 pg per milliliter (normal: 88+/-8, mean +/- S.E.M.) and was distributed in four molecular forms, including free somatostatin. The primary tumor contained 5 microgram of somatostatin-like immunoreactivity per milligram of wet tissue, distributed in three of the molecular forms noted in plasma. Plasma calcitonin was also elevated (4650 pg per milliliter; normal: less than 120). Immunocytochemical studies showed that cells of the primary tumor contained somatostatin and calcitonin but no other peptide hormones. Only somatostatin was present in the metastases. Somatostatin was localized electron microscopically in all secretory granules, irrespective of size and shape, whereas calcitonin was present only within a single subpopulation of small granules in the same cells.
- Find related publications in this database (using NLM MeSH Indexing)
- C-Peptide - secretion
- Celiac Disease - complications
- Cholelithiasis - complications
- Diabetes Complications -
- Glucagon - secretion
- Hormones, Ectopic - analysis
- Humans -
- Hypothalamus - physiopathology
- Islets of Langerhans - physiopathology
- Liver Neoplasms - analysis
- Male -
- Middle Aged -
- Neoplasm Metastasis -
- Pancreatic Neoplasms - analysis Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - secretion Pancreatic Neoplasms - ultrastructure
- Pituitary Gland - physiopathology
- Radioimmunoassay -
- Somatostatin - analysis Somatostatin - immunology Somatostatin - physiology
- Syndrome -