Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Seefeld, U; Krejs, GJ; Siebenmann, RE; Blum, AL.
Esophageal histology in gastroesophageal reflux. Morphometric findings in suction biopsies.
Am J Dig Dis. 1977; 22(11):956-964
Doi: 10.1007/BF01076193
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Esophageal suction biopsies were taken in 24 subjects with proven gastroesophageal reflux, 12 subjects with suspected reflux, and 20 healthy controls. Sixty-two percent of the patients with proven reflux, 33% of the patients with suspected reflux, and 10% of the control subjects had neutrophilic and/or eosinophilic granulocytes in the lamina propria. Lymphocytes, plasma cell, and basophilic granulocytes were shown to be constituents of the normal esophageal mucosa. All epithelial dimensions showed marked individual variations in reflux patients and controls. The relative length of stromal papillae as expressed in percent of total epithelial thickness showed a linear correlation with relative basal cell thickness and an indirect linear correlation with epithelial thickness. Elongation of stromal papillae in proven reflux could only be demonstrated by arbitrary retrospective stratification of the data. Hyperplasia of the basal zone and thinning of the epithelium were not observed in the reflux patients. It is concluded that granulocytic infiltrates and not epithelial alterations are the most prominent histological finding in gastroesophageal reflux.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Basophils - pathology
- Biopsy -
- Eosinophils - pathology
- Epithelium - pathology
- Esophagogastric Junction -
- Esophagus - pathology
- Female -
- Gastroesophageal Reflux - blood Gastroesophageal Reflux - pathology
- Granulocytes - pathology
- Humans -
- Hyperplasia -
- Lymphocytes - pathology
- Male -
- Middle Aged -
- Neutrophils - pathology
- Plasma Cells - pathology
- Suction -