Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Read, NW; Read, MG; Krejs, GJ; Hendler, RS; Davis, G; Fordtran, JS.
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse.
Dig Dis Sci. 1982; 27(3):193-201
Doi: 10.1007/BF01296914
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
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- Abstract:
- The purpose of this paper is to report five patients with chronic secretory diarrhea (maximum stool volume greater than 1 liter per day, duration 6 weeks to 8 years) in whom we could find no evidence of an endocrine tumor or of surreptitious laxative ingestion. All except one had severe hypokalemia. There was apparent improvement after treatment with prednisone in two patients and loperamide in one. The diarrhea resolved spontaneously in three patients and has undergone several temporary remissions in one patient. The last patient died after a severe unremitting illness. Extensive investigations failed to establish the etiology, but intestinal perfusion (carried out in four of the five patients) revealed secretion or abnormally low absorption of water and electrolytes in the jejunum and abnormally low absorption in the colon. The management of patients with chronic watery diarrhea is discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Cathartics - adverse effects
- Chronic Disease -
- Colon - metabolism
- Diarrhea - complications Diarrhea - diagnosis Diarrhea - drug therapy Diarrhea - etiology
- Electrolytes - secretion
- Endocrine System Diseases - physiopathology
- Female -
- Humans -
- Hypokalemia - complications
- Intestinal Absorption -
- Jejunum - metabolism Jejunum - secretion
- Loperamide - therapeutic use
- Male -
- Metabolic Clearance Rate -
- Middle Aged -
- Neoplasms - physiopathology
- Prednisone - therapeutic use
- Substance-Related Disorders -
- Syndrome -
- Water - secretion