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Selected Publication:
Heymann-Mönnikes, I; Taché, Y; Trauner, M; Weiner, H; Garrick, T.
CRF microinjected into the dorsal vagal complex inhibits TRH analog- and kainic acid-stimulated gastric contractility in rats.
Brain Res. 1991; 554(1-2):139-144
Doi: 10.1016/0006-8993(91)90181-T
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- Co-authors Med Uni Graz
- Trauner Michael
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- Abstract:
- The effect of CRF microinjected into the dorsal vagal complex (DVC) on centrally-stimulated gastric contractility was investigated in fasted, urethane-anesthetized rats. Miniature strain gauge force transducers were acutely implanted on the corpus of the stomach and contractility was analyzed by computer. Microinjection of the stable thyrotropin-releasing hormone (TRH) analog, RX 77368, (26 pmol) into the DVC induced a 12.2-fold stimulation of gastric contractility within 30 min. Corticotropin-releasing factor (CRF) (63-210 pmol) microinjected into the DVC concomitantly with RX 77368 (26 pmol) induced a dose-related inhibition of stimulated gastric contractility. Neither CRF alone (210 pmol) nor vehicle modified basal gastric contractility. Microinjection of kainic acid (141 pmol) into the raphe pallidus nucleus induced a 3.6-fold stimulation of gastric contractility after 45 min. This stimulation was suppressed by bilateral microinjection of CRF (105 pmol/site) into the DVC. These results demonstrate that CRF acts in the DVC to inhibit centrally-stimulated gastric contractility and suggest that TRH and CRF may interact in the DVC to regulate gastric motor function.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Corticotropin-Releasing Hormone - administration and dosage Corticotropin-Releasing Hormone - pharmacology
- Dose-Response Relationship, Drug -
- Gastrointestinal Motility - drug effects
- Kainic Acid - pharmacology
- Male -
- Medulla Oblongata - drug effects Medulla Oblongata - physiology
- Microinjections -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects Muscle, Smooth - physiology
- Organ Specificity -
- Pyrrolidonecarboxylic Acid - analogs and derivatives
- Raphe Nuclei - drug effects Raphe Nuclei - physiology
- Rats -
- Rats, Inbred Strains -
- Stomach - drug effects Stomach - physiology
- Thyrotropin-Releasing Hormone - analogs and derivatives Thyrotropin-Releasing Hormone - pharmacology
- Vagus Nerve - drug effects Vagus Nerve - physiology
- Find related publications in this database (Keywords)
- GASTRIC CONTRACTILITY
- CORTICOTROPIN-RELEASING FACTOR
- THYROTROPIN-RELEASING HORMONE
- KAINIC ACID
- DORSAL VAGAL COMPLEX
- RAPHE PALLIDUS