Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Garrick, T; Grijalva, CV; Trauner, M.
Lateral hypothalamic lesions cause gastric injury by stimulating gastric contractility.
Am J Physiol. 1993; 265(1 Pt 1):G138-G142
Doi: 10.1152/ajpgi.1993.265.1.G138
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Trauner Michael
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- Abstract:
- Changes in gastric contractility following lateral hypothalamic (LH) lesions with and without bilateral cervical vagotomy were measured in urethan-anesthetized rats. LH lesions were induced with direct current passed through stereotaxically placed electrodes. Gastric contractility was recorded continuously for 4 h with acutely implanted strain gauge force transducers and analyzed by computer. LH lesions consistently stimulated gastric contractility and caused more gastric mucosal injury than control conditions. Vagotomy blocked both gastric mucosal injury and high-amplitude gastric contractions. In rats with LH lesions and exogenously infused intragastric hydrochloric acid, atropine methyl nitrate inhibited high-amplitude gastric contractions and gastric erosions. These findings indicate that LH lesions stimulate vagally mediated high-amplitude gastric contractions, which, in the presence of hydrochloric acid, cause gastric mucosal erosions.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Gastric Mucosa - pathology
- Gastrointestinal Motility - physiology
- Hypothalamic Area, Lateral - pathology Hypothalamic Area, Lateral - physiopathology
- Male -
- Rats -
- Rats, Sprague-Dawley -
- Stomach - physiopathology
- Stomach Diseases - etiology
- Vagotomy -
- Find related publications in this database (Keywords)
- GASTRIC MOTILITY
- PEPTIC ULCERS
- GASTRIC MUCOSAL DAMAGE