Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fuhrmann, V; Drolz, A; Trauner, M.
Extracorporeal artificial liver support systems in the management of intractable cholestatic pruritus.
Liver Int. 2011; 31 Suppl 3(9):31-33
Doi: 10.1111/j.1478-3231.2011.02584.x
PubMed
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- Co-authors Med Uni Graz
- Trauner Michael
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- Abstract:
- Pruritus can occur as a severe complication of cholestasis. Several hypotheses suggest an important role for the accumulation of bile acids, endogenous opioids and - mire recently - lysophosphatidic acid. Bile acid sequestrants are the first-line therapeutic agents. In refractory cases, a stepwise approach using rifampicin, oral opiate antagonists and the selective serotonin reuptake inhibitor sertraline should be tested. Recent case series reported effective relief of pruritus using extracorporal liver support systems and plasmapheresis.
- Find related publications in this database (using NLM MeSH Indexing)
- Cholestasis - complications
- Cholestyramine Resin - therapeutic use
- Humans -
- Lysophospholipids - metabolism
- Opioid Peptides - antagonists and inhibitors Opioid Peptides - metabolism
- Plasmapheresis - methods
- Pruritus - diagnosis Pruritus - drug therapy Pruritus - metabolism Pruritus - physiopathology Pruritus - therapy
- Renal Dialysis - methods
- Rifampin - therapeutic use
- Sertraline - therapeutic use
- Sorption Detoxification - methods
- Ursodeoxycholic Acid - therapeutic use