Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reich, O; Regauer, S; Tempfer, C; Schneeberger, C; Huber, J.
Polymorphism 1558 C > T in the aromatase gene (CYP19A1) in low-grade endometrial stromal sarcoma
EUR J GYNAECOL ONCOL. 2011; 32(6): 626-627.
Doi: 10.1055/s-0030-1254973
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- Führende Autor*innen der Med Uni Graz
- Reich Olaf
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
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- Abstract:
- Low-grade endometrial stromal sacbmas (ESS) are estrogen-sensitive tumors. Polymorphic variation in the CYP19 gene can affect estrogen synthesis by increasing aromatase activity resulting in elevated levels of estrone and estradiol. We examined the polymorphism 1558 C>T in he aromatase gene (CYP19A1) in a series of 20 low-grade endometrial stromal sarcomas. Archival formalin-fixed and paraffin-embedded material was analyzed with a fast real-time PCR system. The homozygous C/T- and the homozygous mutant T/T-genotypes were detected in 10/20 (50%) and 7/20 (35%) samples, respectively. Polymorphism 1558 C>T in the aromatase gene may represent a high-risk allele with increased local estrogen levels.
- Find related publications in this database (Keywords)
- Endometrial stromal sarcoma
- Aromatase
- CYP19
- Polymorphism
- Single nucleotide polymorhism