Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hauer, C; Urban, C; Slavc, I; Gamillscheg, A; Lackner, H.
Imipenem-antibiotic monotherapy in juvenile cancer patients with neutropenia.
Pediatr Hematol Oncol. 1990; 7(3):229-241
Doi: 10.3109/08880019009033398
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Hauer Almuthe
- Co-Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Lackner Herwig
- Urban Ernst-Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- From 1984 to 1987 two consecutive groups of juvenile cancer patients (n = 45) with fever and neutropenia corresponding in all criteria were examined. In half of the total of 90 febrile episodes and septicemias, a conventional antibiotic combination therapy (Pseudomonas-active penicillin/cephalosporin of the third generation/aminoglycoside) was instituted. In the remaining half imipenem was used as an antibiotic monoagent. In 66% and 60% of the febrile episodes treated with antibiotic combination therapy and with imipenem, respectively, septicemia was confirmed by positive blood cultures. Nineteen febrile episodes occurred in the myeloaplastic phase after bone marrow transplantation. In a comparative study of imipenem as monotherapy versus an antibiotic combination therapy the results obtained with imipenem were superior in many regards. No resistance developed necessitating change of antibiotic therapy. Coagulase-negative Staphylococci, primarily responsible for catheter-associated septicemia, were susceptible. Duration of fever and thus duration of treatment were shorter. The incidence of side effects and costs were lower. Therefore, imipenem as an antibiotic monotherapy in febrile cancer patients with neutropenia appears to be more efficacious than the conventional combination therapy, even during myeloaplasia following bone marrow transplantation. The results and rationale of this retrospective analysis are discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Bone Marrow Transplantation - adverse effects
- Cefotaxime - therapeutic use
- Child - therapeutic use
- Child, Preschool - therapeutic use
- Cilastatin - therapeutic use
- Drug Therapy, Combination - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Imipenem - therapeutic use
- Infant - therapeutic use
- Male - therapeutic use
- Neoplasms - complications
- Neutropenia - complications
- Piperacillin - therapeutic use
- Retrospective Studies - therapeutic use
- Sepsis - drug therapy
- Ticarcillin - therapeutic use
- Tobramycin - therapeutic use