Medizinische Universität Graz - Research portal
Selected Publication:
Steinbrugger, B; Zach, M.
Bronchial reactivity in clinically symptom-free adolescent patients with asthma
MONATSSCHR KINDERHEILK. 1990; 138(7): 389-391.
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- Co-authors Med Uni Graz
- Zach Maximilian
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- Abstract:
- More than half of the pediatric asthma population will become symptomfree during adolescence. We evaluated non-specific airway reactivity by cold air challenge in 42 symptomfree asthma patients, age 8 to 18 years, one year after termination of their anti-asthmatic medication. Twenty-one patients showed a normalized bronchial reactivity, 16 were found to be hyperreactive, and 5 presented with a borderline response. When compared to the normoreactive group, the hyperreactive subjects showed the following statistically significant differences: 1) more allergy by RAST and history (16/16 vs 14/21, p less than 0.05); 2) a significant reduction of mid- and endexpiratory flowrates in baseline lung-function measurements (% pred); maximum expiratory flow at 50% vital capacity: 75% vs 96%, p less than 0.01; maximum expiratory flow at 25% of vital capacity: 71% vs 102%, p less than 0.005). In conclusion, more than one third of our clinically symptom-free patients showed persisting bronchial hyperreactivity; 50% presented with a normalised bronchial response.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Airway Resistance - physiology
- Asthma - diagnosis
- Bronchial Provocation Tests - methods
- Child - methods
- Cold - diagnostic use
- Female - diagnostic use
- Follow-Up Studies - diagnostic use
- Humans - diagnostic use
- Immunoglobulin E - analysis
- Lung Volume Measurements - analysis
- Male - analysis
- Pilot Projects - analysis
- Respiratory Hypersensitivity - diagnosis