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Zobel, G; Pierer, G; Dacar, D; Berger, J; Novak, J.
Extracorporeal CO2 removal in a lung lavage induced respiratory distress syndrome.
INT J ARTIF ORGANS. 1990; 13(7): 430-435. Doi: 10.1177/039139889001300709
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Co-authors Med Uni Graz: Dacar Drago
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Abstract:: Ten pigs with experimental respiratory distress syndrome were treated by extracorporeal CO2 removal (ECCO2-R) combined with low frequency positive pressure ventilation (LPPV). After lung damage had been induced by repeated lung lavages a PEEP trial was conducted in order to find the appropriate PEEP for the damaged lungs. This PEEP was then applied during the ECCO2-R/LPPV period. Blood gas values improved significantly on extracorporeal bypass within a short time (pre-bypass paO2: 54.2 +/- 3.7 vs 168.5 +/- 31.6 mmHg after 15 min on bypass, p less than 0.001) and were kept constant during the next 4 hours. Minute ventilation (MV) was reduced from 4.01 +/- 0.31 to 0.74 +/- 0.07 l/min (p less than 0.0001), FiO2 of the ventilator from 1.0 to 0.46 +/- 0.08 (p less than 0.0001) whereas FiO2 of the membrane lung (ML) was not changed significantly (FIO2ML 0.59 +/- 0.07 vs 0.53 +/- 0.06). During controlled mechanical ventilation (CMV), comparable adequate gas exchange was only achieved at a significantly higher mean airway pressure (Paw 14.1 +/- 0.08 vs 21.2 +/- 0.47 cmH20, p less than 0.0001). Hemodynamic variables did not change significantly during bypass time. ECCO2-R/LPPV driven by a simple renal perfusion system allows adequate gas exchange in experimental respiratory failure.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Extracorporeal Membrane Oxygenation -; Humans -; Infant, Newborn -; Irrigation -; Oxygenators, Membrane -; Positive-Pressure Respiration -; Respiratory Distress Syndrome, Adult - etiology; Swine - etiology