Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Betge, J; Langner, C.
Vascular invasion, perineural invasion, and tumour budding: predictors of outcome in colorectal cancer.
Acta Gastroenterol Belg. 2011; 74(4):516-529
Web of Science
PubMed
- Leading authors Med Uni Graz
- Langner Cord
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- Abstract:
- Tumour stage reflected by the AJCC/UICC TNM system is currently regarded as the most powerful prognostic parameter in patients with colorectal cancer. However, additional histopathological markers are required to improve clinical decision-making with respect to follow-up scheduling and administration of adjuvant therapy. In this review we summarize the available literature regarding the prognostic impact of venous and lymphatic invasion, perineural invasion and tumour budding in colorectal cancer. Special emphasis was placed on patients with AJCC/UICC stage II disease, the risk of lymph node metastasis in early cancer and the prediction of local recurrence in rectal cancer. For each of the markers, the different methods of evaluation, implications resulting from different definitions used in previous studies as well as future perspectives are discussed in detail.
- Find related publications in this database (using NLM MeSH Indexing)
- Colorectal Neoplasms - pathology
- Humans -
- Lymphatic Vessels - pathology
- Neoplasm Invasiveness -
- Neoplasm Recurrence, Local - pathology
- Neoplasm Staging -
- Prognosis -
- Find related publications in this database (Keywords)
- colon cancer
- rectal cancer
- early colorectal cancer
- vascular invasion
- lymphatic invasion
- venous invasion
- lymphovascular invasion
- perineural invasion
- tumour budding
- prognosis
- outcome
- immunohistochemistry
- univariable analysis
- multivariable analysis