Medizinische Universität Graz - Research portal
Selected Publication:
Füchtner, F; Angelberger, P; Kvaternik, H; Hammerschmidt, F; Simovc, BP; Steinbach, J.
Aspects of 6-[18F]fluoro-L-DOPA preparation: precursor synthesis, preparative HPLC purification and determination of radiochemical purity.
Nucl Med Biol. 2002; 29(4):477-481
Doi: 10.1016/S0969-8051(02)00298-6
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- Co-authors Med Uni Graz
- Kvaternik Herbert
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- Abstract:
- A modified method for the synthesis of the intermediate product N-Boc-3,4-di(Boc-O)-6-iodo-L-phenylalanine ethyl ester of the [18F]FDOPA precursor preparation was developed. With the application of bis-(trifluoroacetoxy)-iodobenzene for the iodination step with elemental iodine the yield of the intermediate can be increased from 12% to 50-60%. By replacing silica-gel-based RP HPLC column by a polymer-based column for semi-preparative purification of [18F]FDOPA from the reaction mixture the radiochemical purity of the final product can be increased up to >99%. For the determination of the radiochemical impurity [18F]fluoride a HPLC method using a column with polymer-based RP material was introduced.
- Find related publications in this database (using NLM MeSH Indexing)
- Chromatography, High Pressure Liquid -
- Dihydroxyphenylalanine - analogs and derivatives Dihydroxyphenylalanine - chemical synthesis Dihydroxyphenylalanine - isolation and purification
- Models, Chemical -
- Quality Control -
- Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - isolation and purification
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- 18F
- FDOPA preparation
- FDOPA quality control
- PET