Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Laschober, GT; Ruli, D; Hofer, E; Muck, C; Carmona-Gutierrez, D; Ring, J; Hutter, E; Ruckenstuhl, C; Micutkova, L; Brunauer, R; Jamnig, A; Trimmel, D; Herndler-Brandstetter, D; Brunner, S; Zenzmaier, C; Sampson, N; Breitenbach, M; Fröhlich, KU; Grubeck-Loebenstein, B; Berger, P; Wieser, M; Grillari-Voglauer, R; Thallinger, GG; Grillari, J; Trajanoski, Z; Madeo, F; Lepperdinger, G; Jansen-Dürr, P.
Identification of evolutionarily conserved genetic regulators of cellular aging.
Aging Cell. 2010; 9(6):1084-1097
Doi: 10.1111/j.1474-9726.2010.00637.x
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- Co-Autor*innen der Med Uni Graz
- Hofer Edith
- Ruckenstuhl Rudolf
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- Abstract:
- To identify new genetic regulators of cellular aging and senescence, we performed genome-wide comparative RNA profiling with selected human cellular model systems, reflecting replicative senescence, stress-induced premature senescence, and distinct other forms of cellular aging. Gene expression profiles were measured, analyzed, and entered into a newly generated database referred to as the GiSAO database. Bioinformatic analysis revealed a set of new candidate genes, conserved across the majority of the cellular aging models, which were so far not associated with cellular aging, and highlighted several new pathways that potentially play a role in cellular aging. Several candidate genes obtained through this analysis have been confirmed by functional experiments, thereby validating the experimental approach. The effect of genetic deletion on chronological lifespan in yeast was assessed for 93 genes where (i) functional homologues were found in the yeast genome and (ii) the deletion strain was viable. We identified several genes whose deletion led to significant changes of chronological lifespan in yeast, featuring both lifespan shortening and lifespan extension. In conclusion, an unbiased screen across species uncovered several so far unrecognized molecular pathways for cellular aging that are conserved in evolution.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Aging - genetics
- Child, Preschool -
- Databases, Genetic -
- Evolution, Molecular -
- Gene Expression Regulation -
- Humans -
- Middle Aged -
- Oxidative Stress -
- Saccharomyces cerevisiae - genetics
- Find related publications in this database (Keywords)
- aging
- evolution
- replicative lifespan
- replicative senescence
- senescence
- yeast