Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ruckenstuhl, C; Büttner, S; Carmona-Gutierrez, D; Eisenberg, T; Kroemer, G; Sigrist, SJ; Fröhlich, KU; Madeo, F.
The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer.
PLoS One. 2009; 4(2):e4592-e4592
Doi: 10.1371/journal.pone.0004592
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- Leading authors Med Uni Graz
- Ruckenstuhl Rudolf
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- Abstract:
- BACKGROUND: Otto Warburg observed that cancer cells are often characterized by intense glycolysis in the presence of oxygen and a concomitant decrease in mitochondrial respiration. Research has mainly focused on a possible connection between increased glycolysis and tumor development whereas decreased respiration has largely been left unattended. Therefore, a causal relation between decreased respiration and tumorigenesis has not been demonstrated. METHODOLOGY/PRINCIPAL FINDINGS: For this purpose, colonies of Saccharomyces cerevisiae, which is suitable for manipulation of mitochondrial respiration and shows mitochondria-mediated cell death, were used as a model. Repression of respiration as well as ROS-scavenging via glutathione inhibited apoptosis and conferred a survival advantage during seeding and early development of this fast proliferating solid cell population. In contrast, enhancement of respiration triggered cell death. CONCLUSION/SIGNIFICANCE: Thus, the Warburg effect might directly contribute to the initiation of cancer formation--not only by enhanced glycolysis--but also via decreased respiration in the presence of oxygen, which suppresses apoptosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Death -
- Cell Proliferation -
- Cell Respiration -
- Cell Survival -
- Energy Metabolism -
- Glutathione - pharmacology
- Glycolysis -
- Mitochondria - metabolism
- Models, Biological -
- Neoplasms - metabolism Neoplasms - pathology
- Oxidative Stress -
- Oxygen - metabolism
- Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism