Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rostrup, E; Gouw, AA; Vrenken, H; van Straaten, EC; Ropele, S; Pantoni, L; Inzitari, D; Barkhof, F; Waldemar, G; LADIS study group.
The spatial distribution of age-related white matter changes as a function of vascular risk factors--results from the LADIS study.
Neuroimage. 2012; 60(3):1597-1607
Doi: 10.1016/j.neuroimage.2012.01.106
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ropele Stefan
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- Abstract:
- White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restricted vulnerability remains to be established. The aim of this study was to investigate the spatial distribution of WMH in normally functioning elderly subjects. We introduce a voxel-based approach in which lesion probability is mapped as a function of clinical risk factors using logistic regression, and validate the method using simulated datasets. The method was then applied in a total of 605 participants of the LADIS study (age 74 ± 5 years, all with WMH), and the location of manually delineated WMH was investigated after spatial normalisation. Particularly strong and widespread associations were found for age, gender and hypertension. Different distribution patterns were found for men and women. Further, increased probability was found in association with self-reported alcohol and tobacco consumption, as well as in those with a history of migraine. It is concluded that the location of WMH is dependent on the risk factors involved pointing towards a regionally different pathogenesis and/or vulnerability of the white matter.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Distribution -
- Aged -
- Aged, 80 and over -
- Aging - pathology
- Aging - epidemiology
- Diffusion Tensor Imaging - statistics & numerical data
- Female -
- Humans -
- Incidence -
- Male -
- Middle Aged -
- Models, Neurological -
- Nerve Fibers, Myelinated - pathology
- Reproducibility of Results -
- Risk Assessment -
- Risk Factors -
- Sensitivity and Specificity -
- Sex Distribution -
- Vascular Diseases - epidemiology
- Find related publications in this database (Keywords)
- Ageing
- White matter hyperintensity
- Logistic regression
- Lesion probability mapping
- Risk factors
- MRI