Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kostner, GM; Gries, A; Pometta, M; Molinari, E; Pichler, P; Aicher, H.
Immunochemical determination of lipoprotein Lp(a): comparison of Laurell electrophoresis and ELISA.
Clin Chim Acta. 1990; 188(3):187-192
Doi: 10.1016/0009-8981(90)90200-C
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- Führende Autor*innen der Med Uni Graz
- Kostner Gerhard
- Co-Autor*innen der Med Uni Graz
- Gries Anna
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- Abstract:
- The lipoprotein Lp(a) concentrations in serum from 520 persons (317 men and 203 women) were measured by two different Laurell electrophoresis assays (one in house and one commercial) and by an ELISA technique, using polyclonal antibodies from two different animal species. The following results were obtained. 1. The two Laurell techniques gave similar results. The mean values of all three methods were comparable, whereas median values obtained by ELISA were markedly lower (0.85, 0.97 and 0.057 g/l for the two Laurell assays and the ELISA, respectively). 2. All three methods correlated very well with a correlation coefficient of greater than 0.95. 3. Women had significantly higher values than men (p less than 0.01). It was concluded that Lp(a) serum concentrations in the 'pathological range' could be measured with high enough precision by Laurell electrophoresis and by ELISA using polyclonal antibodies from different animal species.
- Find related publications in this database (using NLM MeSH Indexing)
- Electrophoresis - methods
- Enzyme-Linked Immunosorbent Assay - methods
- Female - methods
- Humans - methods
- Lipoprotein(a) - methods
- Lipoproteins - blood
- Male - blood
- Regression Analysis - blood