Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beubler, E; Horina, G.
5-HT2 and 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat.
Gastroenterology. 1990; 99(1):83-89
Doi: 10.1016/0016-5085(90)91233-V
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- Führende Autor*innen der Med Uni Graz
- Beubler Eckhard
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- Abstract:
- The mechanisms of diarrhea in Asiatic cholera have been studied extensively. Cyclic adenosine monophosphate, 5-hydroxytryptamine (5-HT), prostaglandins, and the function of neuronal structures have been implicated in the pathogenesis of cholera. To elucidate the action of 5-HT in mediating cholera secretion, in vivo experiments were performed in the rat jejunum. The inhibitory effects of the 5-HT2 receptor antagonist ketanserin and the 5-HT3 receptor antagonist ICS 205-930 were studied in cholera toxin- and 5-HT-induced fluid secretion. Both ketanserin and ICS 205-930 dose-dependently but only partially reduced the secretory effect of cholera toxin. The combination of the two blockers totally abolished cholera toxin-induced secretion without any influence on cholera toxin-induced increase in cyclic adenosine monophosphate. Prostaglandin E2- and bisacodyl-induced secretion was not affected by the combined administration of 5-HT2 and 5-HT3 antagonists. The present results provide evidence for an important role of 5-HT in cholera toxin-induced secretion. The data suggest a model in which cholera toxin may initiate the release of 5-HT from enterochromaffin cells. 5-Hydroxytryptamine may then cause prostaglandin E2 formation via 5-HT2 receptors and activation of neuronal structures via 5-HT3 receptors. These two effects may finally lead to the profuse fluid secretion which can be totally blocked by the combination of a 5-HT2 blocker and a 5-HT3 blocker.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bisacodyl - pharmacology
- Cholera Toxin - pharmacology
- Dinoprostone - pharmacology
- Female - pharmacology
- Indoles - pharmacology
- Intestinal Secretions - secretion
- Jejunum - drug effects
- Ketanserin - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Receptors, Serotonin - metabolism
- Serotonin - pharmacology
- Serotonin Antagonists - pharmacology