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Selected Publication:
Juettner, FM; Arian-Schad, K; Porsch, G; Leitner, H; Smolle, J; Ebner, F; Hackl, A; Friehs, G.
Intraoperative radiation therapy combined with external irradiation in nonresectable non-small-cell lung cancer: preliminary report.
Int J Radiat Oncol Biol Phys. 1990; 18(5):1143-1150
Doi: 10.1016/0360-3016(90)90451-o
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- Leading authors Med Uni Graz
- Smolle-Juettner Freyja-Maria
- Co-authors Med Uni Graz
- Ebner Franz
- Kapp Karin S.
- Smolle Josef
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- Abstract:
- Twenty-one patients with nonresectable non-small-cell lung cancer (15 squamous-cell, 4 adeno, 2 large-cell; T1-T3, N0-N2, all M0) underwent lymph node dissection and intraoperative irradiation of the tumor (IORT) with doses between 10 and 20 Gy (energies: 7 to 20 MeV electron beam). Postoperatively, 46-56 Gy external beam irradiation (8 or 23 MeV photon beam) were delivered to the mediastinum and 46 Gy to the tumor bearing area. Fifteen patients were available for follow-up investigations. The CT-scan tumor volumetry 4 weeks postoperatively showed a significant overall decrease (Wilcoxon test: p less than 0.05) with eight minor responses (MR) (tumor regressions between 4 and 45%) and six partial responses (PR) (between 50 and 84%). One case was not evaluable. A second volumetry after external irradiation was done in 14 patients, 18 weeks after IORT, showing 3 complete responses, 10 partial responses (62 to 84%), and 1 minor response (28%). The recent volumetries (10 patients) between 4.5 and 16.5 months after IORT showed 7 complete responses and 3 partial responses (63 to 94%). One patient died from intrabronchial hemorrhage at 7 weeks. Three others died from unrelated causes, 6, 12 and 14 months, respectively, after IORT and in one further case the cause of death at 15 months was local tumor regrowth. Within the median time elapsed since IORT (12 months) only this one case of local regrowth and one further case of distant spread were observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Carcinoma, Non-Small-Cell Lung - diagnostic imaging
- Carcinoma, Non-Small-Cell Lung - radiotherapy
- Carcinoma, Non-Small-Cell Lung - surgery
- Clinical Trials as Topic -
- Combined Modality Therapy -
- Female -
- Humans -
- Intraoperative Period -
- Lung Neoplasms - diagnostic imaging
- Lung Neoplasms - radiotherapy
- Lung Neoplasms - surgery
- Male -
- Middle Aged -
- Radiotherapy Dosage -
- Tomography, X-Ray Computed -