Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Urban, C; Schwinger, W; Slavc, I; Schmid, C; Gamillscheg, A; Lackner, H; Hauer, C; Pakisch, B.
Busulfan/cyclophosphamide plus bone marrow transplantation is not sufficient to eradicate the malignant clone in juvenile chronic myelogenous leukemia.
Bone Marrow Transplant. 1990; 5(5):353-356
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Urban Ernst-Christian
- Co-Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Hauer Almuthe
- Lackner Herwig
- Schwinger Wolfgang
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- Abstract:
- Bone marrow transplantation plays an essential role in the successful treatment of both juvenile and adult chronic myelogenous leukemia. Recently, it has been reported that conditioning with high doses of busulfan can successfully replace total body irradiation (TBI), in patients with acute myelogenous leukemia as well as adult chronic myelogenous leukemia. We report here the case of a 29-month-old boy with juvenile chronic myelogenous leukemia (JCML) transplanted with HLA-identical bone marrow after conditioning with busulfan, etoposide and cyclophosphamide. Successful engraftment was followed by early relapse on day 67. A second HLA-identical transplant was performed following myeloablative treatment with TBI. Engraftment was once again successful and the patient remains free of disease more than 24 months after transplantation. We conclude that busulfan is insufficient in eradicating JCML and that TBI is required prior to transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Bone Marrow Transplantation - therapeutic use
- Busulfan - administration and dosage
- Child, Preschool - administration and dosage
- Cyclophosphamide - administration and dosage
- Humans - administration and dosage
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
- Male - therapy
- Recurrence - therapy
- Remission Induction - methods
- Transplantation, Homologous - methods
- Whole-Body Irradiation - methods