Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Verlohren, S; Herraiz, I; Lapaire, O; Schlembach, D; Moertl, M; Zeisler, H; Calda, P; Holzgreve, W; Galindo, A; Engels, T; Denk, B; Stepan, H.
The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients.
Am J Obstet Gynecol. 2012; 206(1):58.e1-58.e8
Doi: 10.1016/j.ajog.2011.07.037
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Mörtl Manfred Georg
- Schlembach Dietmar
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- Abstract:
- The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders. We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chronic hypertension. sFlt-1 and PlGF were measured in serum samples. Patients with preeclampsia had a significantly increased sFlt-1/PlGF ratio as compared with controls and with patients with chronic and gestational hypertension in <34 weeks and ≥34 weeks (P < .001). Time to delivery was significantly reduced in women with preeclampsia in the highest quartile of the sFlt-1/PlGF ratio (P < .001). The sFlt-1/PlGF ratio allows the identification of women at risk for imminent delivery and is a reliable tool to discriminate between different types of pregnancy-related hypertensive disorders. Copyright © 2012 Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers - blood
- Chronic Disease -
- Female -
- Humans -
- Membrane Proteins - blood
- Pre-Eclampsia - blood
- Pre-Eclampsia - diagnosis
- Pregnancy -
- Pregnancy Outcome -
- Prognosis -
- Vascular Endothelial Growth Factor Receptor-1 - blood
- Find related publications in this database (Keywords)
- gestational hypertension
- placental growth factor
- PIGF
- preeclampsia
- singleton pregnancy
- soluble fms-like tyrosine kinase
- sFlt-1