Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Linortner, P; Fazekas, F; Schmidt, R; Ropele, S; Pendl, B; Petrovic, K; Loitfelder, M; Neuper, C; Enzinger, C.
White matter hyperintensities alter functional organization of the motor system.
NEUROBIOL AGING. 2012; 33(1): 197.e1-197.e9.
Doi: 10.1016/j.neurobiolaging.2010.06.005
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Enzinger Christian
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Koini Marisa
- Linortner Patricia
- Pendl Barbara
- Petrovic Katja-Elisabeth
- Ropele Stefan
- Schmidt Reinhold
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- Abstract:
- Severe white matter hyperintensities (WMH) represent cerebral small vessel disease and predict functional decline in the elderly. We used fMRI to test if severe WMH impact on functional brain network organization even before clinical dysfunction. Thirty healthy right-handed/footed subjects (mean age, 67.8 ± 7.5 years) underwent clinical testing, structural MRI and fMRI at 3.0T involving repetitive right ankle and finger movements. Data were compared between individuals with absent or punctuate (n = 17) and early confluent or confluent (n = 13) WMH. Both groups did not differ in mobility or cognition data. On fMRI, subjects with severe WMH demonstrated excess activation in the pre-supplementary motor area (SMA), frontal, and occipital regions. Activation differences were noted with ankle movements only. Pre-SMA activation correlated with frontal WMH load for ankle but not finger movements. With simple ankle movements and no behavioral deficits, elderly subjects with severe WMH demonstrated pre-SMA activation, usually noted with complex tasks, as a function of frontal WMH load. This suggests compensatory activation related to disturbance of frontosubcortical circuits.
Copyright © 2012 Elsevier Inc. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Ankle - physiopathology
- Cerebral Small Vessel Diseases - diagnosis
- Female -
- Fingers - physiopathology
- Frontal Lobe - pathology
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Motor Cortex - pathology
- Movement -
- Occipital Lobe - pathology
- Find related publications in this database (Keywords)
- White matter hyperintensities
- Aging
- Motor system
- fMRI
- SMA
- Pre-SMA