Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sen, A; Gider, P; Cavalieri, M; Freudenberger, P; Farzi, A; Schallert, M; Reichmann, F; Watzinger, N; Zweiker, R; Schmidt, R; Schmidt, H.
Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study.
Neurodegener Dis. 2012; 10(1-4):135-137
Doi: 10.1159/000334760
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- Führende Autor*innen der Med Uni Graz
- Schmidt Helena
- Sen Abhijit
- Co-Autor*innen der Med Uni Graz
- Cavalieri Margherita
- Farzi Aitak
- Freudenberger Paul
- Gider Pierre
- Reichmann Florian
- Schallert Michael
- Schmidt Reinhold
- Watzinger Norbert
- Zweiker Robert
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- Abstract:
- Background: Physical activity and cardiorespiratory fitness relate to better cognitive performance. Little is known about the effects of fitness on structural brain abnormalities in the elderly. Objective: Assess the association between maximal oxygen consumption (VO(2)max), white matter lesion (WML) volume and brain parenchymal fraction (BPF) in a large cohort of community-dwelling elderly individuals. Methods: The study population consisted of 715 participants of the Austrian Stroke Prevention Study who underwent brain MRI with semi-automated measurement of WML volume (cm(3)) and automated assessment of BPF (%) by the use of SIENAX. A maximal exercise stress test was done on a bicycle ergometer. VO(2)max was calculated based on maximum and resting heart rate. Results: After adjustment for possible confounders, VO2max was independently associated with WML volume (beta = -0.10; p = 0.02); no significant relationship existed with silent cerebral infarcts and BPF. Associations between VO(2)max and WML load were only significant in men, but not in women. Conclusion: Our findings may have important preventive implications because WMLs are known to be a major determinant of cognitive decline and disability in old age. Copyright (C) 2012 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Brain - pathology
- Cohort Studies -
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Leukoencephalopathies - complications Leukoencephalopathies - pathology
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Models, Statistical -
- Oxygen Consumption - physiology
- Physical Fitness -
- Residence Characteristics -
- Sex Factors -
- Stroke - epidemiology Stroke - pathology Stroke - prevention and control
- Find related publications in this database (Keywords)
- Physical activity
- Cardiorespiratory fitness
- Cerebral small-vessel disease
- White matter lesions
- Exercise ECG