Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muscogiuri, G; Sorice, GP; Ajjan, R; Mezza, T; Pilz, S; Prioletta, A; Scragg, R; Volpe, SL; Witham, MD; Giaccari, A.
Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives.
Nutr Metab Cardiovasc Dis. 2012; 22(2): 81-87.
Doi: 10.1016/j.numecd.2011.11.001
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Pilz Stefan
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- Abstract:
- Several studies have shown that vitamin D may play a role in many biochemical mechanisms in addition to bone and calcium metabolism. Recently, vitamin D has sparked widespread interest because of its involvement in the homeostasis of the cardiovascular system. Hypovitaminosis D has been associated with obesity, related to trapping in adipose tissue due to its lipophilic structure. In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which it might modulate cardiovascular risk are not fully understood. Given this background, in this work we summarise clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome. Moreover, we review various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk. Considering the high prevalence of hypovitaminosis D among patients with high cardiovascular risk, vitamin D replacement therapy in this population may be warranted; however, further RCTs are urgently needed to establish when to begin vitamin D therapy, as well as to determine the dose and route and duration of administration.
Copyright © 2011 Elsevier B.V. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Cardiovascular Diseases - blood
- Diabetes Mellitus - blood
- Dietary Supplements -
- Endothelium - drug effects
- Humans -
- Obesity - complications
- Randomized Controlled Trials as Topic -
- Risk Factors -
- Vitamin D - administration and dosage
- Vitamin D Deficiency - blood
- Find related publications in this database (Keywords)
- Vitamin D
- Cardiovascular risk
- Diabetes
- Stroke
- Hypertension
- Endothelial dysfunction
- Ischaemic heart disease
- Dyslipidaemia