Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cavalieri, M; Schmidt, H; Schmidt, R.
Structural MRI in normal aging and Alzheimer's disease: white and black spots.
Neurodegener Dis. 2012; 10(1-4):253-256
Doi: 10.1159/000333120
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cavalieri Margherita
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Schmidt Helena
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- Abstract:
- Background: White matter changes (WMC) and microbleeds (MBs) are common in the elderly and in patients with Alzheimer's disease (AD). Objective: To describe the prevalence, anatomical distribution and longitudinal changes of WMC and MBs in normal aging subjects compared to AD patients and to describe current evidence of their effects on the clinical course of AD. Methods: Short literature review. Results: WMC and MBs are more frequent and progress more rapidly in AD patients than in cognitively normal elderly. New MBs occur in up to one quarter of AD cases without any therapeutic intervention. WMC and MBs influence the clinical course of AD. Conclusion: WMC and MBs might represent treatment targets in clinical trials on AD. Copyright (C) 2012 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - pathology
- Alzheimer Disease - complications
- Brain - pathology
- Humans -
- Image Processing, Computer-Assisted -
- Magnetic Resonance Imaging -
- Nerve Fibers, Myelinated - pathology
- Find related publications in this database (Keywords)
- Normal aging
- Alzheimer's disease
- Brain MRI
- White matter changes
- Microbleeds