Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Chromecki, TF; Jesche, J; Kampel-Kettner, K; Rehak, P; Pummer, K; Zigeuner, R.
Histologic tumor necrosis is an independent prognostic indicator for clear cell and papillary renal cell carcinoma.
Am J Clin Pathol. 2012; 137(2): 283-289.
Doi: 10.1309/AJCPLBK9L9KDYQZP
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Jesche-Chromecki Johanna
- Pummer Karl
- Rehak Peter
- Strini Karin
- Zigeuner Richard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Histologic tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. In papillary renal cell carcinoma (RCC), data regarding the prognostic impact of TN are conflicting. We retrospectively studied the pathology records of 2,333 consecutive patients who underwent nephrectomy from 1984 to 2006 at a single tertiary academic center. In multivariate analyses regarding clear cell RCC, the presence of histologic TN was an independent negative prognostic factor for metastasis-free (hazard ratio [HR], 2.32; confidence interval [CI], 1.86-2.9; P < .001) and overall (HR, 1.52; CI, 1.31-1.76; P < .001) survival. Regarding papillary RCC, the presence of histologic TN represented an independent predictor of metastasis-free (HR, 5.22; CI, 2.2-12.5; P < .001) and overall (HR, 1.69; CI, 1.11-2.58; P = .015) survival. Our findings suggest that the presence of TN is an independent predictor of clinical outcome in clear cell and papillary RCC. Thus, histologic TN might be a reliable prognostic indicator and should, therefore, routinely be examined during pathologic analysis of RCC specimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged - epidemiology
- Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - surgery
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery
- Male -
- Middle Aged -
- Necrosis - pathology
- Neoplasm Staging -
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Find related publications in this database (Keywords)
- Prognosis
- Renal cell carcinoma
- Tumor necrosis
- Papillary type