Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Stelzer, I; Zelzer, S; Raggam, RB; Prüller, F; Truschnig-Wilders, M; Meinitzer, A; Schnedl, WJ; Horejsi, R; Möller, R; Weghuber, D; Reeves, G; Postolache, TT; Mangge, H.
Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation.
Transl Res. 2012; 159(2):118-124
Doi: 10.1016/j.trsl.2011.10.001
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mangge Harald
- Stelzer Ingeborg
- Co-authors Med Uni Graz
- Horejsi Renate
- Meinitzer Andreas
- Möller Reinhard
- Prüller Florian
- Raggam Reinhard Bernd
- Schnedl Wolfgang
- Truschnig-Wilders Martini
- Zelzer Sieglinde
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- Abstract:
- The mechanisms underlying the pathogenesis of obesity-related atherosclerosis remain to be clarified. To investigate the preclinical phase, interleukin-6 (IL-6) plasma levels were analyzed together with clinical, anthropometric, inflammatory, and metabolic variables in a well-defined cohort of 677 young and middle-aged overweight/obese and normal-weight subjects. In the juvenile and adult overweight/obese study group, IL-6 levels were increased significantly compared with normal-weight, age-matched controls (P < 0.001). In both juveniles and adults, higher levels of IL-6 were observed in obese compared with overweight participants. Subjects with metabolic syndrome (MS) had significantly higher IL-6 levels than those without MS. In juveniles, leptin, and in adults, the waist-to-height ratio, turned out to be the best predictor of IL-6 plasma levels in a multiple stepwise regression model. Taken together, in every age group, interleukin-6 is associated positively with the grade of overweight. Interestingly, leptin, which is the best known adipokine, is associated predictively with interleukin-6 plasma levels only in juveniles, which may indicate an important role of this molecule in the initiation of obesity-related inflammation. Copyright © 2012 Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
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- Body Mass Index -
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- Cohort Studies -
- Female -
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- Interleukin-6 - blood
- Leptin - blood
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