Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Liu, JS; Molchanova, TP; Gu, LH; Wilson, JB; Hopmeier, P; Schnedl, W; Balaun, E; Krejs, GJ; Huisman, TH.
Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria.
Hemoglobin. 1992; 16(6):493-501
Doi: 10.3109/03630269208993117
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- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
- Schnedl Wolfgang
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- Abstract:
- Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A1c. Structural analysis of isolated beta chains and sequence analysis of amplified DNA identified a new variant, i.e. Hb Graz that has a His-->Leu replacement at position 2 of the beta chain, in four healthy, apparently unrelated, adults. The second variant was identical to Hb Sherwood Forest or alpha 2 beta 2(104)(G6)Arg-->Thr; it is believed that this may be the second observation of this abnormal hemoglobin.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Amino Acid Sequence - epidemiology
- Base Sequence -
- Genetic Variation - genetics
- Hemoglobins, Abnormal - genetics
- Heterozygote -
- Humans -
- Molecular Sequence Data -
- Mutation - genetics
- Peptide Fragments - genetics