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Lind, P; Langsteger, W; Költringer, P; Lechner, P; Beham, A; Arian Schad, K; Eber, O.
99mTc-labeled monoclonal anti-carcinoembryonic antigen antibody (BW 431/26). Clinical results in the detection of colorectal carcinomas and recurrences.
Scand J Gastroenterol. 1989; 24(10):1205-1211 Doi: 10.3109/00365528909090788
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Co-authors Med Uni Graz: Beham Alfred; Kapp Karin S.
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Abstract:: With the introduction of 99mTc-labeled monoclonal antibodies against carcinoembryonic antigen (CEA) a clinically relevant extension can be expected in the diagnosis of colorectal tumors by immunoscintigraphy (IS). This study comprises a total of 49 patients (primary colorectal tumors, occult neoplasms, and suspicious recurrences), in whom IS with 99mTc monoclonal antibody (MAb) BW 431/26 was performed. After injection of 1100 MBq 99mTc MAb BW 431/26 a whole-body scan was performed in anterior and posterior projection 5 1/2 h later, and SPECT of the abdominal region was done after 6 and 24 h. In the course of primary tumor identification (n = 20) all coloscopically diagnosed and operatively verified carcinomas were confirmed and correctly localized by IS (n = 11). In three patients with positive IS and suspicious coloscopic findings surgery was refused by patients and relatives. In five cases IS was true negative and in 1 case false positive. In the diagnosis of recurrences (n = 29) IS showed an uptake in computer-tomographically and coloscopically suspicious areas in 17 cases. In 12 cases IS was rated negative (11 true-negative findings in scar and granulation tissue, 1 false-negative finding in para-aortal lymph nodes). Elevated serum CEA levels were found only in 17 of 31 patients with true-positive IS. In postoperative cancer care IS with 99mTc-labeled anti-CEA antibody plays a preeminent role in the exclusion or identification of colorectal recurrences.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Antibodies, Monoclonal - administration & dosage; Carcinoembryonic Antigen - analysis; Colonic Neoplasms - diagnostic imaging; Colonic Neoplasms - immunology; Female -; Humans -; Male -; Middle Aged -; Neoplasm Recurrence, Local - diagnostic imaging; Neoplasm Recurrence, Local - immunology; Radionuclide Imaging -; Rectal Neoplasms - diagnostic imaging; Rectal Neoplasms - immunology