Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Putz-Bankuti, C; Pilz, S; Stojakovic, T; Scharnagl, H; Pieber, TR; Trauner, M; Obermayer-Pietsch, B; Stauber, RE.
Association of 25-hydroxyvitamin D levels with liver dysfunction and mortality in chronic liver disease.
Liver Int. 2012; 32(5):845-851
Doi: 10.1111/j.1478-3231.2011.02735.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Putz-Bankuti Csilla
- Stauber Rudolf
- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Pilz Stefan
- Scharnagl Hubert
- Stojakovic Tatjana
- Trauner Michael
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- Abstract:
- Background: Previous studies suggest that chronic liver disease may be related to vitamin D deficiency. It is, however, not known whether 25(OH) D levels are associated with incident hepatic decompensation and mortality in chronic liver failure. Aims: We aimed to evaluate whether 25(OH) D serum levels are associated with Child-Pugh (CP) score, model for end-stage liver disease (MELD) score, occurrence of hepatic decompensation, and survival in patients with cirrhosis. Methods: We enrolled 75 consecutive cirrhotic patients admitted to our outpatient liver clinic (32% females; age: 58 -11 years; aetiology alcohol in 61%). At baseline, 25(OH) D was determined and the degree of liver dysfunction was estimated by CP and MELD score. Thereafter patients were followed-up with respect to hepatic decompensation and mortality. Results: 25(OH) D levels averaged 16.0 -9.2 ng/ ml and were inversely correlated with MELD score (r = -0.34, P = 0.003) and CP score (r = -0.21, P = 0.080). Thirty-seven patients developed hepatic decompensation and 24 patients died during a median follow-up of 3.6 years. Age-and gender-adjusted relative risk (with 95% confidence interval) was 6.37 (1.7523.2; P = 0.005) for hepatic decompensation and 4.31 (1.38-13.5; P = 0.012) for mortality within the first vs the third 25(OH) D tertile but these associations were largely attenuated towards non-significant trends after additional adjustments for CP or MELD score. Conclusions: Our findings show a significant association of 25(OH) D with the degree of liver dysfunction and suggest that low 25(OH) D levels may predict hepatic decompensation and mortality in patients with chronic liver failure.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Comorbidity -
- End Stage Liver Disease - blood End Stage Liver Disease - diagnosis End Stage Liver Disease - mortality
- Female -
- Humans -
- Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - mortality
- Male -
- Middle Aged -
- Severity of Illness Index -
- Survival Rate -
- Vitamin D - analogs and derivatives Vitamin D - blood
- Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - epidemiology