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SHR Neuro Cancer Cardio Lipid Metab Microb

Becker, JC; Schrama, D.
Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.
J INVEST DERMATOL. 2012; 132(1): 15-17. Doi: 10.1038/jid.2011.361 [OPEN ACCESS]
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Leading authors Med Uni Graz: Becker Jürgen Christian
Co-authors Med Uni Graz: Schrama David
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Abstract:: The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-ã-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.
Find related publications in this database (using NLM MeSH Indexing): Animals -; CD4-Positive T-Lymphocytes - immunology; Immune Tolerance - immunology; Oxidoreductases - immunology; Vitiligo - immunology