Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Arian-Schad, K; Leitner, H; Smolle-Jüttner, F; Hackl, A; Porsch, G; Pinter, H; Friehs, G.
[Intraoperative radiotherapy (IORT) at the Graz University Clinics: results of a pilot study on non-small cell lung carcinoma].
Strahlenther Onkol. 1990; 166(3):199-203
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Führende Autor*innen der Med Uni Graz: Kapp Karin S.
Co-Autor*innen der Med Uni Graz: Smolle-Juettner Freyja-Maria
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Abstract:: A pilot study was undertaken during which 15 patients with non-small cell pulmonary carcinomas were exposed to an intraoperative irradiation; twelve out of them were submitted to an additional percutaneous photon therapy. The criteria used to select these patients were functional inoperability, exclusion of remote metastases, and a Karnofsky index greater than 70. Central and peripheral tumors of the stages T1-3, N0-2 were included into the study after histological confirmation of the diagnosis. The local regression rate of the primary tumor can be assessed quite well despite the short follow-up time of 4.5 to 16 months (10 months on an average) which does not yet allow to make a conclusion as to a prolongation of the disease-free survival time. Already two months after the end of external irradiation, a complete remission (CR) was seen in three patients (25%), a partial remission (PR) in seven patients (67%), and a minor remission (MR) in one patient. In the course of further follow-up, the number of complete remissions increased to six (50%). We are encouraged by the small morbidity and a therapeutic response higher than average to continue with this therapy method in patients who, for the time being, are still selected according to strict criteria.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged -; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Carcinoma, Non-Small-Cell Lung - surgery; Combined Modality Therapy -; Evaluation Studies as Topic -; Female -; Follow-Up Studies -; Hospitals, University -; Humans -; Intraoperative Care -; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Lung Neoplasms - surgery; Male -; Middle Aged -; Pilot Projects -; Radiotherapy Dosage -; Time Factors -