Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wagner, D; Kniepeiss, D; Stiegler, P; Sereinigg, M; Zitta, S; Schaffellner, S; Jakoby, E; Müller, H; Iberer, F; Rosenkranz, A; Tscheliessnigg, KH; .
Serum Cystatin C, serum creatinine and the MDRD as predictors for renal function defined by the inulin clearance after orthotopic liver transplantation.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA. 2011; 43(6): 333-337.
Doi: 10.1007/s10353-011-0052-9
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Stiegler Philipp
- Wagner Doris
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Jakoby Estrella
- Kniepeiss Daniela
- Müller Helmut
- Rosenkranz Alexander
- Schaffellner Silvia
- Sereinigg Michael
- Tscheliessnigg Karlheinz
- Zitta Sabine
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- Abstract:
- BACKGROUND: With improved survival post liver transplantation (LT) a highly sensitive and effective monitoring of post-transplant renal function (RF) is mandatory. The aim of this study was to evaluate the prognostic value of cystatin C on RF measured by the inulin clearance 24 months after LT. METHODS: 98 patients were enrolled, serum creatinine and cystatin C were collected prior to transplantation as well as 1, 6, 9, 12 and 24 months thereafter. The inulin clearance was used as reference standard for renal function with a cut off of 100 mL/min to define renal impairment 24 months after LT. All parameters were compared with respect to the defined cutoff. RESULTS: Univariate analysis showed a prognostic impact of antihypertensive medication prior to transplantation (p = 0.0008) and serum cystatin C one month after liver transplantation (p < 0.0001) on renal failure after transplantation. Auroc analysis yielded cystatin C as a superior prognostic parameter compared to creatinine based GFR in predicting renal failure as well as serum creatinine at all time points (AUROC 0.96-0.98). CONCLUSIONS: Our results revealed a high impact of serum cystatin C as an early prognostic biomarker for monitoring renal dysfunction following liver transplantation.
- Find related publications in this database (Keywords)
- CNI-associated nephropathy
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- renal impairment
- cystatin C
- creatinine
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