Medizinische Universität Graz - Research portal
Selected Publication:
Maggi, CA; Astolfi, M; Donnerer, J; Amann, R.
Which mechanisms account for the sensory neuron blocking action of capsaicin on primary afferents in the rat urinary bladder?
Neurosci Lett. 1990; 110(3):267-272
Doi: 10.1016/0304-3940(90)90858-7
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- Co-authors Med Uni Graz
- Donnerer Josef
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- Abstract:
- In the rat isolated bladder, capsaicin produced a concentration-dependent contraction, shown previously to depend upon transmitter release from peripheral endings of primary afferents. When using low concentrations (30-300 nM) of capsaicin, exposure to a second and third dose of capsaicin produced smaller responses than the first application, although a subsequent challenge with 10 microM capsaicin still elicited a contraction which was not reduced as compared to the response produced by the first exposure to a low dose of capsaicin. Capsaicin also evoked a prompt outflow of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI), taken as a marker for sensory nerve activation. A second or third application of a submaximal concentration of the drug was ineffective, although a subsequent challenge with 1 microM capsaicin was effective. These findings indicate that neuropeptide depletion does not necessarily account for the early stage of capsaicin 'desensitization' of primary afferents.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - metabolism
- Capsaicin - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Immunohistochemistry - pharmacology
- Male - pharmacology
- Muscle Contraction - drug effects
- Neurons, Afferent - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Urinary Bladder - drug effects