Medizinische Universität Graz - Research portal
Selected Publication:
Groschner, K.
Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity.
Cardiovasc Res. 2002; 53(1):9-11
Doi: 10.1016/S0008-6363(01)00519-3
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- Leading authors Med Uni Graz
- Groschner Klaus
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- Abstract:
- One impressive function of the vascular endothelium is its ability to adjust the release of vasoactive mediators such as NO and PGI(2) almost instantaneously to changes in blood flow or blood pressure. Besides this fast feedback response to hemodynamic alterations, the endothelium is subject to long-term adaptations that are crucial for prevention of pathological processes such as atherogenesis. Among the various signals that are sensed by endothelial cells, mechanical forces which arise from pulsatile blood flow are probably most important for fast as well as long-term control of blood vessel function by the endothelium.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium Channels - metabolism
- Cell Membrane - metabolism
- Endothelium, Vascular - physiology
- Humans -
- MAP Kinase Signaling System - physiology
- Models, Cardiovascular -
- Phosphorylation -
- Protein Kinases - metabolism
- Proteins - metabolism
- Signal Transduction - physiology
- Stress, Mechanical -
- Find related publications in this database (Keywords)
- vascular endothelium
- Ca2+
- dual mechanosensitivity