Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eder, P; Groschner, K.
TRPC3/6/7: Topical aspects of biophysics and pathophysiology.
Channels (Austin). 2008; 2(2):94-99
Doi: 10.4161/chan.2.2.6015
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- Führende Autor*innen der Med Uni Graz
- Groschner Klaus
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- Abstract:
- Nonselective and lipid-regulated cation channels formed by TRPC3, TRPC6 and TRPC7 have recently obtained attention in view their potential pathophysiological impact. It appears as a particular challenge to understand the molecular basis of TRPC3/6/7-related diseases in order to further delineate their value as therapeutic targets. The multifunctional nature of these channel proteins, based on a complex, versatile heteromerization potential along with highly promiscuous gating and mixed cation permeation properties, make these channels pivotal players in cellular signaling networks. Here we summarize newsworthy aspects of TRPC3/6/7 physiology and pathophysiology that open the view on novel therapeutic strategies based on these TRPCs as target structures.
- Find related publications in this database (using NLM MeSH Indexing)
- Drug Delivery Systems - methods
- Drug Discovery -
- Humans -
- TRPC Cation Channels - drug effects TRPC Cation Channels - physiology
- Find related publications in this database (Keywords)
- TRPC3
- TRPC6
- TRPC7
- Ca2+ homeostasis
- lipid signaling
- TRP-related diseases