Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Baumgartner, W; Hohenthanner, K; Höfer, GF; Groschner, K; Romanin, C.
Estimating the number of channels in patch-clamp recordings: application to kinetic analysis of multichannel data from voltage-operated channels.
Biophys J. 1997; 72(3):1143-1152
Doi: 10.1016/S0006-3495(97)78763-0
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- Co-Autor*innen der Med Uni Graz
- Groschner Klaus
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- Abstract:
- Important kinetic information of voltage-operated ion channels can be obtained by estimating the open probability, the availability, and the first latency, and by applying run analysis. In the case of multichannel patches, estimation of the number of available channels is a prerequisite for the above analysis. Here we describe a method for calculation of the a posteriori probability of the number of available channels in each sweep by using the Bayes formula. This probability serves as a measure for the number of channels and allows for first latency determination and run analysis. The methods described were applied to simulated and experimental data obtained from L-type Ca2+ channel recordings.
- Find related publications in this database (using NLM MeSH Indexing)
- Bayes Theorem -
- Calcium Channels - chemistry Calcium Channels - physiology
- Calcium Channels, L-Type -
- Ion Channel Gating -
- Ion Channels - chemistry Ion Channels - physiology
- Kinetics -
- Models, Theoretical -
- Patch-Clamp Techniques -