Medizinische Universität Graz - Research portal
Selected Publication:
Groschner, K; Schuhmann, K; Baumgartner, W; Pastushenko, V; Schindler, H; Romanin, C.
Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.
FEBS Lett. 1995; 373(1):30-34
Doi: 10.1016/0014-5793(95)01012-4
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- Leading authors Med Uni Graz
- Groschner Klaus
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- Abstract:
- The role of cellular phosphatase activity in regulation of smooth muscle L-type Ca2+ channels was investigated using tautomycin, a potent and specific inhibitor of serin/threonin phosphatases type 1 and 2A. Tautomycin (1-100 nM) inhibited Ca2+ channel activity in smooth muscle cells isolated from human umbilical vein. Tautomycin-induced inhibition of Ca2+ channel activity was due to a reduction of channel availability which originated mainly from prolongation of the lifetime of unavailable states of the channel. Pretreatment of smooth muscle cells with the protein kinase inhibitor H-7 (10 microM) prevented the inhibitory effect of tautomycin. Our results suggest modulation of slow gating between available and unavailable states as a mechanism of phosphorylation-dependent down-regulation of Ca2+ channels in vascular smooth muscle.
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- Calcium Channels, L-Type -
- Culture Media -
- Humans -
- Ion Channel Gating -
- Membrane Potentials - drug effects
- Muscle Proteins - physiology
- Muscle, Smooth, Vascular - physiology
- Pyrans -
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- Find related publications in this database (Keywords)
- L-TYPE CA2+ CHANNEL
- PROTEIN PHOSPHATASE
- CELLULAR REGULATION
- VASCULAR SMOOTH MUSCLE
- PATCH CLAMP